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Cut-off levels

What is a cut-off level??
As per AS/NZ 4308:2008  - Urine Screening
  • Cut-off levels are a measurement by which a drug test is deemed to be either negative or non-negative
  • Cut-off levels vary  for each  individual drug class  and are determined by the AS/NZ 4308:2008 Drug Testing Standards
  • Traces of a drug or its metabolite may be found in urine, but must exceed a pre-determined amount to be deemed non-negative.
  • In New Zealand the AS/NZ 4308:2008 Standard dictates the cut-off levels for both immunoassay (on-site) screening and laboratory confirmations
The two tables below demonstrate the  cut-off levels for immunoassay screening  (table 1) and laboratory confirmations (table 2)  urine


Table 1
The AS/NZ 4308:2008
Immunoassay screen cut-off levels are :
Amphetamine
type substances            300ng/ml

Benzodiazepines           200ng/ml

Cannabis
Metabolites                  50ng/ml

Cocaine
Metabolites                  300ng/ml

Opiates                       300ng/ml


Table 2
Laboratory  cut- off levels for confirmations are
as per AS/NZ 4308:2008 Standard

COMPOUND              GC/MS (Confirmation)

Amphetamines
Methylamphetamine
Methylenedioxy-
methylamphetamine         150ng/ml
Methyldndeioxy-
amphetamine

Benzylpiperazine*
Phentermine*
Ephedrine*                     500ng/ml
Psuedoephedrine


Diazepam
Nordizepam
Oxazepam                    200ng/ml
Temazepam


A-hydroxyl-airprazolam
7-amino-clonazepam
7-amino-flunitrazepam     100ng/ml
7-amino-nitrazepam


11-nor-delta-9                 15ng/ml
Tetrahydrocannabinol-9-Carboxylic acid


Benzoylecgonine
Ecgonine methyl ester     150ng/ml


Codeine                       300ng/ml
Morphine                     300ng/ml  
6-Acetylmorphine*           10ng/ml    
*These drugs may be optionally tested within each
class and the specified cut-off levels shall apply